SMER28

• Catalog No.: S8197
• CAS Number: 307538-42-7
• M. F.: C11H10BrN3
• M. W.: 264.1212
• Purity: >99% (HPLC)

SYNONYMS

• IUPAC name: 6-bromo-N-(prop-2-en-1-yl)quinazolin-4-amine
• IUPAC Traditional name: 6-bromo-N-(prop-2-en-1-yl)quinazolin-4-amine
• Synonyms: 6-Bromo-N-2-propenyl-4-quinazolinamine

DATABASE IDS

• CAS Number: 307538-42-7
• MDL Number: MFCD02166825

PROPERTIES

• Empirical Formula (Hill Notation): C11H10BrN3
• Purity: >99% (HPLC)
• Apperance: solid
• Solubility: DMSO: >20 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H318-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 37/38-41
• Safety Statements: 26-36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Description (简体中文)

Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.