10058-F4

• Catalog No.: F3680
• CAS Number: 403811-55-2
• M. F.: C12H11NOS2
• M. W.: 249.35184
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• IUPAC Traditional name: 5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• Synonyms: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

DATABASE IDS

• CAS Number: 403811-55-2
• MDL Number: MFCD00758517

PROPERTIES

• Empirical Formula (Hill Notation): C12H11NOS2
• Purity: ≥98% (HPLC)
• Apperance: yellow solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: <2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317-H319
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 36-43
• Safety Statements: 26-36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. It is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 mM using c-Myc transfected Rat1a fibroblasts).

Description (简体中文)

Biochem/physiol Actions
10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. It is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 mM using c-Myc transfected Rat1a fibroblasts).