Ro 27-3225 trifluoroacetate salt

• Catalog No.: R3905
• M. F.: C39H52N12O6
• M. W.: 784.90698
• Purity: ≥98% (reversed phase HPLC)

SYNONYMS

• Title: Ro273225 三氟乙酸盐
• IUPAC name: (2S)-2-[(2S)-2-[(2S)-2-butanamido-3-(1H-imidazol-4-yl)propanamido]-3-phenylpropanamido]-5-carbamimidamido-N-[(1S)-1-[(carbamoylmethyl)(methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]pentanamide
• IUPAC Traditional name: (2S)-2-[(2S)-2-[(2S)-2-butanamido-3-(1H-imidazol-4-yl)propanamido]-3-phenylpropanamido]-5-carbamimidamido-N-[(1S)-1-[carbamoylmethyl(methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]pentanamide
• Synonyms: Butir-His-D-Phe-Arg-Trp-Sar-NH2 三氟乙酸盐; Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoroacetate salt

DATABASE IDS

• MDL Number: MFCD04112656

PROPERTIES

• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: room temp
• German water hazard class: 3
• Empirical Formula (Hill Notation): C39H52N12O6 · xC2HF3O2
• Purity: ≥98% (reversed phase HPLC)
• Apperance: white lyophilized solid
• Solubility: H2O: >10 mg/mL

DETAILS

Description (简体中文)

Amino Acid Sequence
Butir-His-Phe-Arg-Trp-Sar-NH2
Biochem/physiol Actions
Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.

Description (English)

Amino Acid Sequence
Butir-His-Phe-Arg-Trp-Sar-NH2
Biochem/physiol Actions
Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.