6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

• Catalog No.: P5499
• CAS Number: 866405-64-3
• M. F.: C24H25N5O
• M. W.: 399.4882
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
• IUPAC Traditional name: 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
• Synonyms: Dorsomorphin; Compound C; AMPK Inhibitor

DATABASE IDS

• MDL Number: MFCD08705402
• CAS Number: 866405-64-3
• PubChem SID: 24898658

PROPERTIES

• Empirical Formula (Hill Notation): C24H25N5O
• Purity: ≥98% (HPLC)
• Apperance: white to beige powder
• Solubility: DMSO: >2 mg/mL (warmed)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H312-H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• Safety Statements: 36/37
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomorphin also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP).

Description (简体中文)

Biochem/physiol Actions
Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomorphin also acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP).