AMN082

• Catalog No.: A6605
• CAS Number: 97075-46-2
• M. F.: C28H30Cl2N2
• M. W.: 465.4572
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: (diphenylmethyl)({2-[(diphenylmethyl)amino]ethyl})amine dihydrochloride
• IUPAC Traditional name: (diphenylmethyl)({2-[(diphenylmethyl)amino]ethyl})amine dihydrochloride
• Synonyms: N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride

DATABASE IDS

• PubChem SID: 24891112
• CAS Number: 97075-46-2
• MDL Number: MFCD08702723

PROPERTIES

• Empirical Formula (Hill Notation): C28H28N2 · 2HCl
• Purity: ≥98% (HPLC)
• Apperance: white to off-white solid
• Solubility: DMSO: ≥5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H400
• European Hazard Symbols: Harmful (Xn)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P273
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 22-50
• Safety Statements: 61
• Storage Condition: desiccated
• Storage Temperature: -20°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Application
AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.
Biochem/physiol Actions
AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC50 = 64 nM) and stimulates GTPγS binding (EC50 = 290 nM) similar to L-AP4 and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.

Description (简体中文)

Application
AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.
Biochem/physiol Actions
AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC50 = 64 nM) and stimulates GTPγS binding (EC50 = 290 nM) similar to L-AP4 and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.