IDR-1

• Catalog No.: I6409
• M. F.: C65H118N18O15
• M. W.: 1391.74402
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2,6-diamino-N-[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-{[(2S,3S)-1-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-hydroxyethyl]carbamoyl}-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}ethyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}butyl]carbamoyl}-2-hydroxyethyl]hexanamide
• IUPAC Traditional name: (2S)-2,6-diamino-N-[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-{[(2S,3S)-1-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-hydroxyethyl]carbamoyl}-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}ethyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}butyl]carbamoyl}-2-hydroxyethyl]hexanamide
• Synonyms: [H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2]; H-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-NH2; Innate defense regulator peptide-1; KSRIVPAIPVSLL-NH2; KSRIVPAIPVSLL

PROPERTIES

• Compostion: Protein content, ~91%
• Empirical Formula (Hill Notation): C65H118N18O15
• Purity: ≥95% (HPLC)
• Apperance: lyophilized powder (provided as TFA salt)
• Solubility: H2O: soluble >1 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-NH2
Biochem/physiol Actions
IDR-1 is an anti-infective peptide that acts on the host to stimulate the innate immune response. IDR-1 is believed to act by enhancing monocyte chemokines, while reducing pro-inflammatory cytokines (decreased TNF and IL-6 and increased IL-10).

Description (简体中文)

Amino Acid Sequence
Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-NH2
Biochem/physiol Actions
IDR-1 is an anti-infective peptide that acts on the host to stimulate the innate immune response. IDR-1 is believed to act by enhancing monocyte chemokines, while reducing pro-inflammatory cytokines (decreased TNF and IL-6 and increased IL-10).