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Rifaximin

Catalog No. R9904 Name Sigma Aldrich
CAS Number 80621-81-4 Website http://www.sigmaaldrich.com
M. F. C43H51N3O11 Telephone 1-800-521-8956
M. W. 785.87854 Fax
Purity Email
Storage Chembase ID: 153978

SYNONYMS

Title
利福西亚胺
IUPAC name
methyl (7S,11R,12R,13R,14R,15R,16R,17R,18R)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaene-13-carboxylate
IUPAC Traditional name
methyl (7S,11R,12R,13R,14R,15R,16R,17R,18R)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaene-13-carboxylate
Synonyms
利福昔明
4-Deoxy-4′-methylpyrido[1′,2′-1,2]imidazo[5,4-c]rifamycin SV
Rifacol
4-脱氧-4′-甲基吡啶并[1′,2′-1,2]咪唑并[5,4-c]利福霉素 SV

DATABASE IDS

CAS Number 80621-81-4
MDL Number MFCD00864973

PROPERTIES

Empirical Formula (Hill Notation) C43H51N3O11
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS KD1576000
Storage Temperature 2-8°C
German water hazard class 2

DETAILS

Description (English)
Application
Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species of Staphylococcus, Streptococcus and Enterococcus. It is less active against species of Enterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator1.
Biochem/physiol Actions
Rifaximin is a semisynthetic antibiotic used to treat diarrhea caused by E. coli. It is also used to treat hepatic encephalopathy by reducing blood ammonia concentrations. Rifaximin is a potential treatment for inflammatory bowel disease1.
Description (简体中文)
Application
Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species of Staphylococcus, Streptococcus and Enterococcus. It is less active against species of Enterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator1.
Biochem/physiol Actions
Rifaximin is a semisynthetic antibiotic used to treat diarrhea caused by E. coli. It is also used to treat hepatic encephalopathy by reducing blood ammonia concentrations. Rifaximin is a potential treatment for inflammatory bowel disease1.

REFERENCES