L-β-threo-benzyl-aspartate ammonium salt

• Catalog No.: B6436
• CAS Number: 871123-98-7(freeacid)
• M. F.: C11H16N2O4
• M. W.: 240.25574
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• Title: L-β-threo-benzyl-aspartate
• IUPAC name: (2S,3S)-2-amino-3-benzylbutanedioic acid amine
• IUPAC Traditional name: (2S,3S)-2-amino-3-benzylbutanedioic acid amine
• Synonyms: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt; (2S,3S)-2-Amino-3-benzylsuccinic acid; DL-TBOA

DATABASE IDS

• CAS Number: 871123-98-7(freeacid)

PROPERTIES

• Empirical Formula (Hill Notation): C11H13NO4 · xNH3
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: H2O: >10 mg/mL
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
L-β-threo-benzyl-aspartate is a preferential EAAT3 excitatory amino acid transporter antagonist. The product exhibits 10-fold selectivity for EAAT3, Ki = 0.8 μM for EAAT3 in C17.2 neuroprogenitor cells expressing hEAATs (vs. Ki of 8.7 μM for EAAT1 and Ki of 10 μM for EAAT2). L-β-threo-benzyl-aspartate is a useful tool for studying the EAAT2 pharmacophore.

Description (简体中文)

Biochem/physiol Actions
L-β-threo-benzyl-aspartate is a preferential EAAT3 excitatory amino acid transporter antagonist. The product exhibits 10-fold selectivity for EAAT3, Ki = 0.8 μM for EAAT3 in C17.2 neuroprogenitor cells expressing hEAATs (vs. Ki of 8.7 μM for EAAT1 and Ki of 10 μM for EAAT2). L-β-threo-benzyl-aspartate is a useful tool for studying the EAAT2 pharmacophore.