Sematilide monohydrochloride monohydrate

• Catalog No.: S0323
• CAS Number: 101526-62-9(freebase)
• M. F.: C14H26ClN3O4S
• M. W.: 367.89194
• Purity: ≥99% (HPLC)
• Storage: desiccated

SYNONYMS

• Title: Sematilide 单盐酸盐 一水合物
• IUPAC name: N-[2-(diethylamino)ethyl]-4-methanesulfonamidobenzamide hydrate hydrochloride
• IUPAC Traditional name: sematilide hydrate hydrochloride
• Synonyms: N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide 单盐酸盐 一水合物; CK-1752A; N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide monohydrochloride monohydrate

DATABASE IDS

• MDL Number: MFCD11041004
• CAS Number: 101526-62-9(freebase)

PROPERTIES

• Empirical Formula (Hill Notation): C14H23N3O3S· HCl · H2O
• Purity: ≥99% (HPLC)
• Apperance: white solid
• Solubility: H2O: ≥16 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.

Description (简体中文)

Biochem/physiol Actions
Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.