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Sematilide monohydrochloride monohydrate_Molecular_structure_CAS_101526-62-9(freebase))
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Sematilide monohydrochloride monohydrate

Catalog No. S0323 Name Sigma Aldrich
CAS Number 101526-62-9(freebase) Website http://www.sigmaaldrich.com
M. F. C14H26ClN3O4S Telephone 1-800-521-8956
M. W. 367.89194 Fax
Purity ≥99% (HPLC) Email
Storage desiccated Chembase ID: 153969

SYNONYMS

Title
Sematilide 单盐酸盐 一水合物
IUPAC name
N-[2-(diethylamino)ethyl]-4-methanesulfonamidobenzamide hydrate hydrochloride
IUPAC Traditional name
sematilide hydrate hydrochloride
Synonyms
N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide 单盐酸盐 一水合物
CK-1752A
N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide monohydrochloride monohydrate

DATABASE IDS

MDL Number MFCD11041004
CAS Number 101526-62-9(freebase)

PROPERTIES

Empirical Formula (Hill Notation) C14H23N3O3S· HCl · H2O
Purity ≥99% (HPLC)
Apperance white solid
Solubility H2O: ≥16 mg/mL
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Condition desiccated
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.
Description (简体中文)
Biochem/physiol Actions
Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.

REFERENCES