SD-208

• Catalog No.: S7071
• CAS Number: 627536-09-8
• M. F.: C17H10ClFN6
• M. W.: 352.7529032
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
• IUPAC Traditional name: 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
• Synonyms: 2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine

DATABASE IDS

• MDL Number: MFCD11519969
• PubChem SID: 24899731
• CAS Number: 627536-09-8

PROPERTIES

• Empirical Formula (Hill Notation): C17H10ClFN6
• Purity: ≥98% (HPLC)
• Apperance: off-white to tan powder
• Solubility: DMSO: >5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

Description (简体中文)

Biochem/physiol Actions
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.