CyPPA

• Catalog No.: C5493
• CAS Number: 73029-73-9
• M. F.: C16H23N5
• M. W.: 285.38732
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
• IUPAC Traditional name: N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
• Synonyms: Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

DATABASE IDS

• MDL Number: MFCD01550586
• CAS Number: 73029-73-9

PROPERTIES

• Empirical Formula (Hill Notation): C16H23N5
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: <2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335-H413
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

Description (简体中文)

Biochem/physiol Actions
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.