ICRF-193

• Catalog No.: I4659
• CAS Number: 21416-88-6
• M. F.: C12H18N4O4
• M. W.: 282.29572
• Purity: ≥95%

SYNONYMS

• IUPAC name: 4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
• IUPAC Traditional name: 4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
• Synonyms: meso-4,4′-(3,2-butanediyl)-bis(2,6-piperazinedione)

DATABASE IDS

• MDL Number: MFCD01702964
• PubChem SID: 24896062
• CAS Number: 21416-88-6

PROPERTIES

• Empirical Formula (Hill Notation): C12H18N4O4
• Purity: ≥95%
• Solubility: DMSO: soluble4 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H317
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280-P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22-43
• RTECS: TL6380200
• Safety Statements: 36/37
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.1 Induces apoptosis in several cell lines including K562 and Molt-4 cells.2,,,1 ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α3, and may in addition cause DNA strand breaks.4

Description (简体中文)

Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.1 Induces apoptosis in several cell lines including K562 and Molt-4 cells.2,,,1 ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α3, and may in addition cause DNA strand breaks.4