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ICRF-193_Molecular_structure_CAS_21416-88-6)
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ICRF-193

Catalog No. I4659 Name Sigma Aldrich
CAS Number 21416-88-6 Website http://www.sigmaaldrich.com
M. F. C12H18N4O4 Telephone 1-800-521-8956
M. W. 282.29572 Fax
Purity ≥95% Email
Storage Chembase ID: 153963

SYNONYMS

IUPAC name
4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
IUPAC Traditional name
4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
Synonyms
meso-4,4′-(3,2-butanediyl)-bis(2,6-piperazinedione)

DATABASE IDS

MDL Number MFCD01702964
PubChem SID 24896062
CAS Number 21416-88-6

PROPERTIES

Empirical Formula (Hill Notation) C12H18N4O4
Purity ≥95%
Solubility DMSO: soluble4 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301-H317
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P280-P301 + P310
RID/ADR UN 2811 6.1/PG 3
Risk Statements 22-43
RTECS TL6380200
Safety Statements 36/37
Storage Temperature -20°C
Hazard Class 6.1
UN Number 2811
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.1 Induces apoptosis in several cell lines including K562 and Molt-4 cells.2,,,1 ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α3, and may in addition cause DNA strand breaks.4
Description (简体中文)
Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.1 Induces apoptosis in several cell lines including K562 and Molt-4 cells.2,,,1 ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α3, and may in addition cause DNA strand breaks.4

REFERENCES