Ciproxifan hydrochloride

• Catalog No.: C6492
• CAS Number: 1049741-81-2
• M. F.: C16H19ClN2O2
• M. W.: 306.78726
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole hydrochloride
• IUPAC Traditional name: 4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole hydrochloride
• Synonyms: Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride

DATABASE IDS

• PubChem SID: 24724449
• MDL Number: MFCD08705321
• CAS Number: 1049741-81-2

PROPERTIES

• Empirical Formula (Hill Notation): C16H18N2O2 · HCl
• Purity: ≥98% (HPLC)
• Apperance: off-white solid
• Solubility: DMSO: soluble30 mg/mL
• Solubility: water, high purity: soluble30 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• Storage Condition: desiccated
• Storage Condition: under inert gas
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

Description (简体中文)

Biochem/physiol Actions
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.