CI 976

• Catalog No.: C3743
• CAS Number: 114289-47-3
• M. F.: C23H39NO4
• M. W.: 393.56006
• Purity: >98% (HPLC)

SYNONYMS

• IUPAC name: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
• IUPAC Traditional name: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
• Synonyms: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

DATABASE IDS

• CAS Number: 114289-47-3
• MDL Number: MFCD00869662

PROPERTIES

• Empirical Formula (Hill Notation): C23H39NO4
• Purity: >98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: insoluble <2 mg/mL
• GHS Hazard statements: H413
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

Description (简体中文)

Biochem/physiol Actions
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.