RG108

• Catalog No.: R8279
• CAS Number: 48208-26-0
• M. F.: C19H16N2O4
• M. W.: 336.34134
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-(1,3-dioxo-2,3,5,6-tetrahydro-1H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
• IUPAC Traditional name: (2S)-2-(1,3-dioxo-5,6-dihydroisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
• Synonyms: N-Phthalyl-L-tryptophan

DATABASE IDS

• CAS Number: 48208-26-0
• PubChem SID: 24724594

PROPERTIES

• Empirical Formula (Hill Notation): C19H14N2O4
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: >10 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.

Description (简体中文)

Biochem/physiol Actions
RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.