Cilnidipine

• Catalog No.: C1493
• CAS Number: 132203-70-4
• M. F.: C27H28N2O7
• M. W.: 492.52042
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 3-(2-methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: 3-(2-methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: FRC 8653; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester

DATABASE IDS

• MDL Number: MFCD00865853
• PubChem SID: 24892414
• CAS Number: 132203-70-4

PROPERTIES

• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 41
• RTECS: US7975550
• Safety Statements: 26-39
• Storage Condition: protect from light
• German water hazard class: 3
• GHS Signal Word: Danger
• GHS Hazard statements: H318
• European Hazard Symbols: Irritant (Xi)
• Empirical Formula (Hill Notation): C27H28N2O7
• Purity: ≥98% (HPLC)
• Apperance: light yellow powder
• Solubility: H2O: ≤2 mg/mL
• Solubility: DMSO: ≥20 mg/mL

DETAILS

Description (English)

Packaging
Protect from high temperatures.
Biochem/physiol Actions
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

Description (简体中文)

包装
Protect from high temperatures.
Biochem/physiol Actions
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.