Cucurbitacin I hydrate_Molecular_structure_CAS_2222-07-3(anhydrous))

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Cucurbitacin I hydrate
Catalog No.	C4493	Name	Sigma Aldrich
CAS Number	2222-07-3(anhydrous)	Website	http://www.sigmaaldrich.com
M. F.	C30H44O8	Telephone	1-800-521-8956
M. W.	532.66556	Fax
Purity	≥97% (HPLC)	Email
Storage		Chembase ID: 153944

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SYNONYMS

Title

Cucurbitacin I

IUPAC name

(1R,2R,10S,11S,13R,14R,15R)-14-[(2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-4,13-dihydroxy-1,6,6,11,15-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,7-diene-5,17-dione hydrate

IUPAC Traditional name

(1R,2R,10S,11S,13R,14R,15R)-14-[(2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-4,13-dihydroxy-1,6,6,11,15-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,7-diene-5,17-dione hydrate

Synonyms

2,16α,20,25-tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione

Elatericin B

NSC 521777

JSI-124

DATABASE IDS

CAS Number	2222-07-3(anhydrous)
EC Number	218-736-8

PROPERTIES

Empirical Formula (Hill Notation)	C30H42O7 · xH2O
Purity	≥97% (HPLC)
Apperance	white to off-white solid
Solubility	DMSO: >5 mg/mL
GHS Pictograms
GHS Signal Word	Danger
GHS Hazard statements	H300
European Hazard Symbols	Highly toxic (T+)
MSDS Link	Download
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements	P264-P301 + P310
RID/ADR	UN 2811 6.1/PG 1
Risk Statements	28
RTECS	RC6200000
Safety Statements	28-36/37-45
Storage Temperature	-20°C
Hazard Class	6.1
UN Number	2811
Packing Group	1
German water hazard class	3

DETAILS

Description (English)

Biochem/physiol Actions
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

Description (简体中文)