TMPH hydrochloride

• Catalog No.: T5576
• CAS Number: 849461-91-2
• M. F.: C16H32ClNO2
• M. W.: 305.88378
• Purity: (Product is pure based on CHN, NMR and MS results)
• Storage: under inert gas

SYNONYMS

• IUPAC name: 2,2,6,6-tetramethylpiperidin-4-yl heptanoate hydrochloride
• IUPAC Traditional name: 2,2,6,6-tetramethylpiperidin-4-yl heptanoate hydrochloride
• Synonyms: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate hydrochloride

DATABASE IDS

• PubChem SID: 24724633
• CAS Number: 849461-91-2
• MDL Number: MFCD08277030

PROPERTIES

• Empirical Formula (Hill Notation): C16H32ClNO2
• Purity: (Product is pure based on CHN, NMR and MS results)
• Apperance: white solid
• Solubility: H2O: soluble22 mg/mL at ~60 °C
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H317-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 36/37/38-43
• Safety Statements: 26-36/37
• Storage Condition: under inert gas
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.

Description (简体中文)

Biochem/physiol Actions
2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.