Cibenzoline succinate

• Catalog No.: C1618
• CAS Number: 100678-32-8
• M. F.: C22H24N2O4
• M. W.: 380.43696
• Purity: ≥97% (NMR)

SYNONYMS

• Title: Cibenzoline 琥珀酸盐
• IUPAC name: 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole; butanedioic acid
• IUPAC Traditional name: cibenzoline; succinic acid
• Synonyms: 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate; Cibenol; Cipralan; Exacor

DATABASE IDS

• MDL Number: MFCD00941423
• CAS Number: 100678-32-8
• PubChem SID: 24892426

PROPERTIES

• Empirical Formula (Hill Notation): C18H18N2 ·C4H6O4
• Purity: ≥97% (NMR)
• Apperance: white to off-white solid
• Solubility: H2O: ≥5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Risk Statements: 22
• RTECS: EJ9960100
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

Description (简体中文)

Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.