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Cibenzoline succinate

Catalog No. C1618 Name Sigma Aldrich
CAS Number 100678-32-8 Website http://www.sigmaaldrich.com
M. F. C22H24N2O4 Telephone 1-800-521-8956
M. W. 380.43696 Fax
Purity ≥97% (NMR) Email
Storage Chembase ID: 153936

SYNONYMS

Title
Cibenzoline 琥珀酸盐
IUPAC name
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole; butanedioic acid
IUPAC Traditional name
cibenzoline; succinic acid
Synonyms
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
Cibenol
Cipralan
Exacor

DATABASE IDS

MDL Number MFCD00941423
CAS Number 100678-32-8
PubChem SID 24892426

PROPERTIES

Empirical Formula (Hill Notation) C18H18N2 ·C4H6O4
Purity ≥97% (NMR)
Apperance white to off-white solid
Solubility H2O: ≥5 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Risk Statements 22
RTECS EJ9960100
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
Description (简体中文)
Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

REFERENCES