AR-A014418

• Catalog No.: A3230
• CAS Number: 487021-52-3
• M. F.: C12H12N4O4S
• M. W.: 308.31308
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
• IUPAC Traditional name: 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
• Synonyms: N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea

DATABASE IDS

• CAS Number: 487021-52-3
• MDL Number: MFCD08277040

PROPERTIES

• Empirical Formula (Hill Notation): C12H12N4O4S
• Purity: ≥98% (HPLC)
• Apperance: off-white to tan solid
• Solubility: DMSO: ≥20 mg/mL, clear, light yellow
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H318-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 22-37/38-41
• Safety Statements: 26-36/39
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.

Description (简体中文)

Biochem/physiol Actions
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.