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Sordarin sodium salt_Molecular_structure_CAS_463356-00-5)
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Sordarin sodium salt

Catalog No. S1442 Name Sigma Aldrich
CAS Number 463356-00-5 Website http://www.sigmaaldrich.com
M. F. C27H39NaO8 Telephone 1-800-521-8956
M. W. 514.58353 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 153926

SYNONYMS

Title
Sordarin sodium salt 钠盐
IUPAC name
sodium (1R,2S,4R,5R,8R,9S,11R)-2-({[(2R,3S,4S,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyloxan-2-yl]oxy}methyl)-9-formyl-5-methyl-13-(propan-2-yl)tetracyclo[7.4.0.02,11.04,8]tridec-12-ene-1-carboxylate
IUPAC Traditional name
sodium (1R,2S,4R,5R,8R,9S,11R)-2-({[(2R,3S,4S,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyloxan-2-yl]oxy}methyl)-9-formyl-13-isopropyl-5-methyltetracyclo[7.4.0.02,11.04,8]tridec-12-ene-1-carboxylate

DATABASE IDS

PubChem SID 24899480
CAS Number 463356-00-5
MDL Number MFCD08277029

PROPERTIES

Biological Source from Sordaria araneosa
Empirical Formula (Hill Notation) C27H39NaO8
Purity ≥98% (HPLC)
Shipped in wet ice
Apperance solid
Solubility H2O: soluble ≤10 mg/mL
MSDS Link Download
German water hazard class 3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C

DETAILS

Description (English)
Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.
Description (简体中文)
Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

REFERENCES