Scyllatoxin

• Catalog No.: S2321
• CAS Number: 116235-63-3
• M. F.: C142H243N45O39S7
• M. W.: 3429.18192
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (4S)-4-{[(1R)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-carbamoyl-2-(1H-imidazol-4-yl)ethyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-sulfanylethyl]carbamoyl}-4-[(2R)-2-[(2S)-6-amino-2-[(2S)-2-{2-[(2S,3S)-2-[(2R)-2-[(2S)-6-amino-2-{2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-aminopropanamido]-3-phenylpropanamido]-3-sulfanylpropanamido]-3-carbamoylpropanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-sulfanylpropanamido]-4-carbamoylbutanamido]-4-methylpentanamido]-3-hydroxypropanamido]-3-sulfanylpropanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]-4-methylpentanamido]acetamido}-4-methylpentanamido]-4-methylpentanamido]acetamido}hexanamido]-3-sulfanylpropanamido]-3-methylpentanamido]acetamido}-3-carboxypropanamido]hexanamido]-3-sulfanylpropanamido]butanoic acid
• IUPAC Traditional name: (4S)-4-{[(1R)-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-carbamoyl-2-(1H-imidazol-4-yl)ethyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-sulfanylethyl]carbamoyl}-4-[(2R)-2-[(2S)-6-amino-2-[(2S)-2-{2-[(2S,3S)-2-[(2R)-2-[(2S)-6-amino-2-{2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-aminopropanamido]-3-phenylpropanamido]-3-sulfanylpropanamido]-3-carbamoylpropanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-sulfanylpropanamido]-4-carbamoylbutanamido]-4-methylpentanamido]-3-hydroxypropanamido]-3-sulfanylpropanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]-4-methylpentanamido]acetamido}-4-methylpentanamido]-4-methylpentanamido]acetamido}hexanamido]-3-sulfanylpropanamido]-3-methylpentanamido]acetamido}-3-carboxypropanamido]hexanamido]-3-sulfanylpropanamido]butanoic acid
• Synonyms: LeTx I scorpion toxin; Leiurotoxin I

DATABASE IDS

• MDL Number: MFCD00671413
• CAS Number: 116235-63-3

PROPERTIES

• Purity: ≥95% (HPLC)
• Recombinant: expressed in E. coli
• Shipped in: wet ice
• Apperance: lyophilized powder
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2
Reconstitution
Stock solution of 1 μm can be obtained by adding 0.292 mL of any conventional buffer per μg of protein.
Biochem/physiol Actions
Recombinant peptide of scyllatoxin, a 31 amino acid long toxin, originally isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus; selective blocker of apamin-sensitive small-conductance Ca2+-activated K+ channels (SK channels) with highest affinity towards Kca2.2.

Description (简体中文)

Amino Acid Sequence
Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2
Reconstitution
Stock solution of 1 μm can be obtained by adding 0.292 mL of any conventional buffer per μg of protein.
Biochem/physiol Actions
Recombinant peptide of scyllatoxin, a 31 amino acid long toxin, originally isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus; selective blocker of apamin-sensitive small-conductance Ca2+-activated K+ channels (SK channels) with highest affinity towards Kca2.2.