5-(4-Phenoxybutoxy)psoralen

• Catalog No.: P6124
• CAS Number: 870653-45-5
• M. F.: C21H18O5
• M. W.: 350.36462
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one
• IUPAC Traditional name: 4-(4-phenoxybutoxy)furo[3,2-g]chromen-7-one
• Synonyms: PAP-1

DATABASE IDS

• CAS Number: 870653-45-5
• MDL Number: MFCD11114059
• PubChem SID: 24724583

PROPERTIES

• Empirical Formula (Hill Notation): C21H18O5
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: DMSO: soluble9 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H334
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P342 + P311
• Risk Statements: 42/43
• Safety Statements: 22-36/37-45
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.

Description (简体中文)

Biochem/physiol Actions
Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.