DCPIB

• Catalog No.: D4068
• CAS Number: 82749-70-0
• M. F.: C22H28Cl2O4
• M. W.: 427.36132
• Purity: ≥98% (HPLC)
• Storage: under inert gas

SYNONYMS

• IUPAC name: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]butanoic acid
• IUPAC Traditional name: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid
• Synonyms: 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid

DATABASE IDS

• MDL Number: MFCD07783995
• PubChem SID: 24724462
• CAS Number: 82749-70-0

PROPERTIES

• Empirical Formula (Hill Notation): C22H28Cl2O4
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: DMSO: >40 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H318-H413
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P280-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-41
• Safety Statements: 26-36/39-45
• Storage Condition: under inert gas
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
DCPIB is a potent inhibitor of the volume-sensitive anion channel (VSAC). IC50 = 4.1μM ) versus ICl,swell in calf pulmonary artery endothelial (CPAE) cells. DCPIB does not inhibit CPAE cell ICl,Ca; hCFTR; nor guinea pig ICl,PKA, IKr, IKs,IKl, INa and ICa. DCPIB inhibition is reversible and voltage independent. ICl,swell is believed to be important in cardiovascular function. Studies have been limited by the lack of specific ligands.

Description (简体中文)

Biochem/physiol Actions
DCPIB is a potent inhibitor of the volume-sensitive anion channel (VSAC). IC50 = 4.1μM ) versus ICl,swell in calf pulmonary artery endothelial (CPAE) cells. DCPIB does not inhibit CPAE cell ICl,Ca; hCFTR; nor guinea pig ICl,PKA, IKr, IKs,IKl, INa and ICa. DCPIB inhibition is reversible and voltage independent. ICl,swell is believed to be important in cardiovascular function. Studies have been limited by the lack of specific ligands.