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Borrelidin

Catalog No. B3061 Name Sigma Aldrich
CAS Number 7184-60-3 Website http://www.sigmaaldrich.com
M. F. C28H43NO6 Telephone 1-800-521-8956
M. W. 489.64412 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 153918

SYNONYMS

IUPAC name
(1R,2R)-2-[(2S,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid
IUPAC Traditional name
(1R,2R)-2-[(2S,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid
Synonyms
Borrelidine
NSC 216128
Treponemycin
2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid
Cyclopentanecarboxylic acid

DATABASE IDS

MDL Number MFCD01740784
PubChem SID 24724417
CAS Number 7184-60-3

PROPERTIES

Biological Source from Streptomyces parvulus
Empirical Formula (Hill Notation) C28H43NO6
Purity ≥98% (HPLC)
Shipped in wet ice
Solubility DMSO: soluble1 mg/mL
Solubility methanol: soluble1 mg/mL
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS ED8750000
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.
Description (简体中文)
Biochem/physiol Actions
Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.

REFERENCES