JNJ-10198409

• Catalog No.: J4649
• CAS Number: 627518-40-5
• M. F.: C18H16FN3O2
• M. W.: 325.3369432
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-(3-fluorophenyl)-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-3-amine
• IUPAC Traditional name: N-(3-fluorophenyl)-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-3-amine
• Synonyms: N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine; RWJ 540973; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine

DATABASE IDS

• CAS Number: 627518-40-5

PROPERTIES

• Empirical Formula (Hill Notation): C18H16FN3O2
• Purity: ≥98% (HPLC)
• Apperance: off-white solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: <2 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.

Description (简体中文)

Biochem/physiol Actions
JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.