IRAK-1/4 Inhibitor I

• Catalog No.: I5409
• M. F.: C20H21N5O4
• M. W.: 395.41184
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-{1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl}-3-nitrobenzamide
• IUPAC Traditional name: N-{1-[2-(morpholin-4-yl)ethyl]-1,3-benzodiazol-2-yl}-3-nitrobenzamide
• Synonyms: N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole; 1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole

DATABASE IDS

• MDL Number: MFCD09752602

PROPERTIES

• Empirical Formula (Hill Notation): C20H21N5O4
• Purity: ≥98% (HPLC)
• Apperance: off-white to light yellow solid
• Solubility: DMSO: ≥5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38
• Safety Statements: 26-36/37-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
IRAK-1/4 Inhibitor I is a novel benzimidazole that is a potent inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK 1/4). IC50 values were 300 nM and 200 nM for IRAK-1 and -4, respectively, and >10,000 nM for a panel of 27 other kinases tested.

Description (简体中文)

Biochem/physiol Actions
IRAK-1/4 Inhibitor I is a novel benzimidazole that is a potent inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK 1/4). IC50 values were 300 nM and 200 nM for IRAK-1 and -4, respectively, and >10,000 nM for a panel of 27 other kinases tested.