TPCA-1

• Catalog No.: T1452
• CAS Number: 507475-17-4
• M. F.: C12H10FN3O2S
• M. W.: 279.2901032
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
• IUPAC Traditional name: 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
• Synonyms: GW683965; GW683965A; [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

DATABASE IDS

• CAS Number: 507475-17-4
• MDL Number: MFCD09037541

PROPERTIES

• Empirical Formula (Hill Notation): C12H10FN3O2S
• Purity: ≥95% (HPLC)
• Apperance: off-white powder
• Solubility: DMSO: ≥10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H319
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 22-36
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

Description (简体中文)

Biochem/physiol Actions
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.