LY-364947

• Catalog No.: L6293
• CAS Number: 396129-53-6
• M. F.: C17H12N4
• M. W.: 272.30398
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline
• IUPAC Traditional name: 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline
• Synonyms: HTS 466284; 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline; Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

DATABASE IDS

• PubChem SID: 24724526
• CAS Number: 396129-53-6
• MDL Number: MFCD00800758

PROPERTIES

• Empirical Formula (Hill Notation): C17H12N4
• Purity: ≥98% (HPLC)
• Gene Information: human ... TGFBR1(7046)
• Apperance: tan solid
• Solubility: H2O: <2 mg/mL
• Solubility: DMSO: >5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335-H400
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P273-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38-50/53
• Safety Statements: 26-45-60-61
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.

Description (简体中文)

Biochem/physiol Actions
LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.