Fumitremorgin C

• Catalog No.: F9054
• CAS Number: 118974-02-0
• M. F.: C22H25N3O3
• M. W.: 379.4522
• Purity: >98% (HPLC and TLC)

SYNONYMS

• IUPAC name: (1S,12S,15S)-7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0^3,^1^1.0^4,^9.0^1^5,^1^9]icosa-3(11),4,6,8-tetraene-14,20-dione
• IUPAC Traditional name: (1S,12S,15S)-7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0^3,^1^1.0^4,^9.0^1^5,^1^9]icosa-3(11),4,6,8-tetraene-14,20-dione
• Synonyms: FTC

DATABASE IDS

• CAS Number: 118974-02-0
• PubChem SID: 24724486
• MDL Number: MFCD08702652

PROPERTIES

• Biological Source: from Neosartorya fischeri
• Empirical Formula (Hill Notation): C22H25N3O3
• Purity: >98% (HPLC and TLC)
• Shipped in: wet ice
• Apperance: film
• Solubility: acetonitrile: soluble5 mg/mL
• Solubility: methanol: soluble5 mg/mL
• Solubility: DMSO: soluble
• Solubility: chloroform: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Packaging
Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.
Biochem/physiol Actions
Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco-protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.

Description (简体中文)

包装
Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.
Biochem/physiol Actions
Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco-protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.