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Fenobam

Catalog No. F0430 Name Sigma Aldrich
CAS Number 57653-26-6 Website http://www.sigmaaldrich.com
M. F. C11H11ClN4O2 Telephone 1-800-521-8956
M. W. 266.68364 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 127404

SYNONYMS

IUPAC name
1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
IUPAC Traditional name
fenobam
Synonyms
N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

DATABASE IDS

CAS Number 57653-26-6
PubChem SID 24894721
MDL Number MFCD00868019

PROPERTIES

Empirical Formula (Hill Notation) C11H11ClN4O2
Purity ≥98% (HPLC)
Apperance white solid
Solubility DMSO: >20 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H300
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements P264-P301 + P310
RID/ADR UN 2811 6.1/PG 3
Risk Statements 25
Safety Statements 45
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 2811
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
Description (简体中文)
Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.

REFERENCES