Desvenlafaxine hydrochloride

• Catalog No.: D2069
• CAS Number: 300827-87-6
• M. F.: C16H26ClNO2
• M. W.: 299.83614
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• Title: Desvenlafaxine Hydrochloride
• IUPAC name: 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol hydrochloride
• IUPAC Traditional name: desvenlafaxine hydrochloride
• Synonyms: 4-[2-(Dimethylamino)-1-(1-Hydroxycyclohexyl)Ethyl]-Phenol Hydrochloride

DATABASE IDS

• MDL Number: MFCD11045287
• CAS Number: 300827-87-6

PROPERTIES

• Empirical Formula (Hill Notation): C16H25NO2 · HCl
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• Solubility: H2O: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H319
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 22-36
• Safety Statements: 26
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.

Description (简体中文)

Biochem/physiol Actions
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.