M344

• Catalog No.: M5820
• CAS Number: 251456-60-7
• M. F.: C16H25N3O3
• M. W.: 307.388
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 7-{[4-(dimethylamino)phenyl]formamido}-N-hydroxyheptanamide
• IUPAC Traditional name: 7-{[4-(dimethylamino)phenyl]formamido}-N-hydroxyheptanamide
• Synonyms: N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide; MS 344, D237; 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide

DATABASE IDS

• MDL Number: MFCD03453554
• CAS Number: 251456-60-7

PROPERTIES

• Empirical Formula (Hill Notation): C16H25N3O3
• Purity: ≥98% (HPLC)
• Apperance: white to beige powder
• Solubility: DMSO: soluble10 mg/mL, clear
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
M344 is a HDAC inhibitor; subtype selective for HDAC6 over HDAC1. M344 inhibits HDAC (IC50 = 100 nM) and also inhibits hyperacetylation of histone H4, terminal cell differentiation, transcription (γ-globin), and tumor cell death.

Description (简体中文)

Biochem/physiol Actions
M344 is a HDAC inhibitor; subtype selective for HDAC6 over HDAC1. M344 inhibits HDAC (IC50 = 100 nM) and also inhibits hyperacetylation of histone H4, terminal cell differentiation, transcription (γ-globin), and tumor cell death.