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ITSA-1

Catalog No. I4159 Name Sigma Aldrich
CAS Number 200626-61-5 Website http://www.sigmaaldrich.com
M. F. C13H7Cl2N3O Telephone 1-800-521-8956
M. W. 292.12018 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 153870

SYNONYMS

IUPAC name
1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole
IUPAC Traditional name
1-(2,4-dichlorobenzoyl)-1,2,3-benzotriazole
Synonyms
N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide
Inhibitor-1 of Trichostatin A
1-(2,4-Dichlorobenzoyl)-1H-benzotriazole

DATABASE IDS

CAS Number 200626-61-5
MDL Number MFCD00195103
PubChem SID 24724515

PROPERTIES

Empirical Formula (Hill Notation) C13H7Cl2N3O
Purity ≥98% (HPLC)
Apperance solid
Solubility DMSO: ~28 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Risk Statements 22
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.
Description (简体中文)
Biochem/physiol Actions
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.

REFERENCES