ITSA-1

• Catalog No.: I4159
• CAS Number: 200626-61-5
• M. F.: C13H7Cl2N3O
• M. W.: 292.12018
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole
• IUPAC Traditional name: 1-(2,4-dichlorobenzoyl)-1,2,3-benzotriazole
• Synonyms: N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide; Inhibitor-1 of Trichostatin A; 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole

DATABASE IDS

• CAS Number: 200626-61-5
• MDL Number: MFCD00195103
• PubChem SID: 24724515

PROPERTIES

• Empirical Formula (Hill Notation): C13H7Cl2N3O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ~28 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.

Description (简体中文)

Biochem/physiol Actions
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.