N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

• Catalog No.: B3436
• CAS Number: 300670-16-0
• M. F.: C19H14Br2N2O3S
• M. W.: 510.19906
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-(4-bromophenyl)-3-[(4-bromophenyl)sulfamoyl]benzamide
• IUPAC Traditional name: N-(4-bromophenyl)-3-[(4-bromophenyl)sulfamoyl]benzamide
• Synonyms: C2-8

DATABASE IDS

• CAS Number: 300670-16-0
• MDL Number: MFCD00355835
• PubChem SID: 24724418

PROPERTIES

• Empirical Formula (Hill Notation): C19H14Br2N2O3S
• Purity: ≥98% (HPLC)
• Apperance: off-white solid
• Solubility: DMSO: ~20 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H319-H413
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 36
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

Description (简体中文)

Biochem/physiol Actions
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.