SIS3

• Catalog No.: S0447
• CAS Number: 521984-48-5
• M. F.: C28H28ClN3O3
• M. W.: 489.99322
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-{1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl}prop-2-en-1-one hydrochloride
• IUPAC Traditional name: 1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-{1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl}prop-2-en-1-one hydrochloride
• Synonyms: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone 盐酸盐; (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

DATABASE IDS

• PubChem SID: 24724599
• CAS Number: 521984-48-5
• MDL Number: MFCD09265258

PROPERTIES

• Empirical Formula (Hill Notation): C28H27N3O3 · HCl
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: H2O: <2 mg/mL
• Solubility: DMSO: >20 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3

Description (简体中文)

Biochem/physiol Actions
SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3