Aurothioglucose hydrate

• Catalog No.: A0606
• CAS Number: 12192-57-3(anhydrous)
• M. F.: C6H13AuO6S
• M. W.: 410.19537
• Purity: ≥97% (titration)
• Storage: desiccated

SYNONYMS

• IUPAC name: (2R,3R,4S,5S,6R)-2-(auriosulfanyl)-6-(hydroxymethyl)oxane-3,4,5-triol hydrate
• IUPAC Traditional name: aurothioglucose hydrate
• Synonyms: Solganol; Solganal; Gold thioglucose

DATABASE IDS

• PubChem SID: 24724383
• CAS Number: 12192-57-3(anhydrous)
• EC Number: 235-365-7

PROPERTIES

• Empirical Formula (Hill Notation): C6H11AuO5S · xH2O
• Purity: ≥97% (titration)
• Apperance: off-white powder
• Solubility: H2O: >5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• Safety Statements: 22-36/37-45
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Description (简体中文)

Biochem/physiol Actions
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.