Pifithrin-μ

• Catalog No.: P0122
• CAS Number: 64984-31-2
• M. F.: C8H7NO2S
• M. W.: 181.21168
• Purity: ≥97% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: phenylethynesulfonamide
• IUPAC Traditional name: phenylethynesulfonamide
• Synonyms: PFTμ; PFT-μ; 2-Phenyl-ethynesulfoanide; 2-Phenylethynesulfonamide

DATABASE IDS

• MDL Number: MFCD00181531
• PubChem SID: 24724568
• CAS Number: 64984-31-2

PROPERTIES

• Empirical Formula (Hill Notation): C8H7NO2S
• Purity: ≥97% (HPLC)
• Apperance: solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: <2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.

Description (简体中文)

Biochem/physiol Actions
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.