Mephetyl tetrazole

• Catalog No.: M7945
• CAS Number: 916923-10-9
• M. F.: C20H22N4O
• M. W.: 334.41488
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-[2-(4-methoxyphenyl)ethyl]-5-[1-(4-methylphenyl)cyclopropyl]-1H-1,2,3,4-tetrazole
• IUPAC Traditional name: 1-[2-(4-methoxyphenyl)ethyl]-5-[1-(4-methylphenyl)cyclopropyl]-1,2,3,4-tetrazole
• Synonyms: 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole

DATABASE IDS

• CAS Number: 916923-10-9
• MDL Number: MFCD11045297

PROPERTIES

• Empirical Formula (Hill Notation): C20H22N4O
• Purity: ≥98% (HPLC)
• Apperance: pale yellow oil
• Solubility: DMSO: >5 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

Description (简体中文)

Biochem/physiol Actions
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.