Supercinnamaldehyde

• Catalog No.: S3322
• CAS Number: 70351-51-8
• M. F.: C12H11NO2
• M. W.: 201.22124
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-methyl-3-(2-oxopropylidene)-2,3-dihydro-1H-indol-2-one
• IUPAC Traditional name: 1-methyl-3-(2-oxopropylidene)indol-2-one
• Synonyms: 1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one

DATABASE IDS

• CAS Number: 70351-51-8
• MDL Number: MFCD08530327

PROPERTIES

• Empirical Formula (Hill Notation): C12H11NO2
• Purity: ≥98% (HPLC)
• Apperance: red solid
• Solubility: H2O: insoluble <2 mg/mL
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38-52/53
• Safety Statements: 26-36/37-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Caution
Air-sensitive
Biochem/physiol Actions
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC50 = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.

Description (简体中文)

Caution
Air-sensitive
Biochem/physiol Actions
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC50 = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.