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Levetiracetam

Catalog No. L8668 Name Sigma Aldrich
CAS Number 102767-28-2 Website http://www.sigmaaldrich.com
M. F. C8H14N2O2 Telephone 1-800-521-8956
M. W. 170.20896 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 70537

SYNONYMS

IUPAC name
(2S)-2-(2-oxopyrrolidin-1-yl)butanamide
IUPAC Traditional name
levetiracetam
Synonyms
(αS)-α-Ethyl-2-oxo-1-pyrrolidineacetamide
Keppra®
2(S)-(2-oxopyrrolidin-1-yl)butyramide

DATABASE IDS

CAS Number 102767-28-2
MDL Number MFCD03265610

PROPERTIES

Empirical Formula (Hill Notation) C8H14N2O2
Purity ≥98% (HPLC)
Apperance white powder
Solubility H2O: >5 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H319
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P305 + P351 + P338
Risk Statements 22-36
RTECS UX9656166
Safety Statements 26
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Levetiracetam is a pyrrolidine with antiepileptic activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
Description (简体中文)
Biochem/physiol Actions
Levetiracetam is a pyrrolidine with antiepileptic activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
法律信息
Keppra 注册商标 UCB Pharma, S.A.

REFERENCES