NIDA-41020

• Catalog No.: N8162
• CAS Number: 502486-89-7
• M. F.: C23H24Cl2N4O2
• M. W.: 459.36826
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
• IUPAC Traditional name: 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(piperidin-1-yl)pyrazole-3-carboxamide
• Synonyms: 1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

DATABASE IDS

• CAS Number: 502486-89-7
• MDL Number: MFCD08277026

PROPERTIES

• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P264-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38
• Safety Statements: 26-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• Empirical Formula (Hill Notation): C23H24Cl2N4O2
• Purity: ≥97% (HPLC)
• Apperance: off-white solid
• Solubility: DMSO: ~16 mg/mL
• Solubility: H2O: insoluble

DETAILS

Description (English)

Biochem/physiol Actions
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].

Description (简体中文)

Biochem/physiol Actions
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].