5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide

• Catalog No.: B2311
• CAS Number: 681281-88-9
• M. F.: C31H27IN4S
• M. W.: 614.54235
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-(1,3-benzothiazol-2-yl)-3-ethyl-2-{2-[methyl(phenyl)amino]ethenyl}-1-phenyl-1H-1,3-benzodiazol-3-ium iodide
• IUPAC Traditional name: 6-(1,3-benzothiazol-2-yl)-1-ethyl-2-{2-[methyl(phenyl)amino]ethenyl}-3-phenyl-1,3-benzodiazol-1-ium iodide

DATABASE IDS

• CAS Number: 681281-88-9
• PubChem SID: 24724416
• MDL Number: MFCD00570739

PROPERTIES

• Empirical Formula (Hill Notation): C31H27IN4S
• Purity: ≥98% (HPLC)
• Apperance: orange solid
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)-ethenyl]-1-phenyl-1H-benzimidazolium or Akt Inhibitor IV is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 0.625μM) and cell proliferation (IC₅₀ < 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.

Description (简体中文)

Biochem/physiol Actions
5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)-ethenyl]-1-phenyl-1H-benzimidazolium or Akt Inhibitor IV is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 0.625μM) and cell proliferation (IC₅₀ < 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.