BAY U6751 hydrate

• Catalog No.: B3686
• CAS Number: 114290-51-6(anhydrous)
• M. F.: C20H22ClNNa2O7
• M. W.: 469.82372
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: disodium 4-(2-chlorophenyl)-1-ethyl-6-methyl-5-[(propan-2-yloxy)carbonyl]-1,4-dihydropyridine-2,3-dicarboxylate hydrate
• IUPAC Traditional name: disodium 4-(2-chlorophenyl)-1-ethyl-5-(isopropoxycarbonyl)-6-methyl-4H-pyridine-2,3-dicarboxylate hydrate
• Synonyms: 4-(2-Chlorophenyl)-1-ethyl-1,4-dihydro-6-methyl-2,3,5-pyridinetricarboxylic acid 5-isopropyl ester disodium salt hydrate

DATABASE IDS

• MDL Number: MFCD08705410
• CAS Number: 114290-51-6(anhydrous)
• PubChem SID: 24891730

PROPERTIES

• Empirical Formula (Hill Notation): C20H20ClNNa2O6 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: H2O: >8 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Caution
Light sensitive. Store in amber vials.
Biochem/physiol Actions
BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output.

Description (简体中文)

Caution
Light sensitive. Store in amber vials.
Biochem/physiol Actions
BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output.