Ionomycin calcium salt

• Catalog No.: I3909
• M. F.: C41H70CaO9
• M. W.: 747.0671
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: Ionomycin caicium salt 钙盐
• IUPAC name: (7R,9S,11S)-14-[(2R,4R,8R,9R,10S,11S)-9,11-dihydroxy-12-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,8,10-trimethyldodec-6-en-2-yl]-7,9,11-trimethyl-1,3-dioxa-2-calcacyclotetradec-13-ene-4,12-dione
• IUPAC Traditional name: (7R,9S,11S)-14-[(2R,4R,8R,9R,10S,11S)-9,11-dihydroxy-12-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,8,10-trimethyldodec-6-en-2-yl]-7,9,11-trimethyl-1,3-dioxa-2-calcacyclotetradec-13-ene-4,12-dione

DATABASE IDS

• EC Number: 200-664-3
• MDL Number: MFCD00083634

PROPERTIES

• Biological Source: from Streptomyces conglobatus
• Concentration: 1 mM in DMSO
• Empirical Formula (Hill Notation): C41H70CaO9
• Purity: ≥98% (HPLC)
• Quality Level: PREMIUM
• Shipped in: wet ice
• Sterility: 0.2 μm filtered
• Flash Point: 87 °C
• Flash Point: 188.6 °F
• Personal Protective Equipment: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• Storage Temperature: -20°C
• German water hazard class: 1

DETAILS

Description (English)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination 1, inhibit adrenal bovine TREK-1 channels 2, and to regulate cell division of mature human B cells 3. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. Product I3909 is a Ready Made Solution, from Streptomyces conglobatus. The concentration is 1 Mm in DMSO and it is 0.2 μm filtered.
Biochem/physiol Actions
Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination 1 and inhibits adrenal bovine TREK-1 channels2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Description (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination 1, inhibit adrenal bovine TREK-1 channels 2, and to regulate cell division of mature human B cells 3. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. Product I3909 is a Ready Made Solution, from Streptomyces conglobatus. The concentration is 1 Mm in DMSO and it is 0.2 μm filtered.
Biochem/physiol Actions
Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination 1 and inhibits adrenal bovine TREK-1 channels2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information