Nα-Methylhistamine dihydrochloride

• Catalog No.: H5914
• CAS Number: 16503-22-3
• M. F.: C6H13Cl2N3
• M. W.: 198.09352
• Purity: (The product is pure based on elemental analysis results, NMR and MS spectra.)

SYNONYMS

• IUPAC name: [2-(1H-imidazol-4-yl)ethyl](methyl)amine dihydrochloride
• IUPAC Traditional name: [2-(1H-imidazol-4-yl)ethyl](methyl)amine dihydrochloride
• Synonyms: NAMH dihydrochloride; N-Methyl-1H-imidazole-4-ethanamine dihydrochloride

DATABASE IDS

• CAS Number: 16503-22-3
• PubChem SID: 24724503
• MDL Number: MFCD00134838

PROPERTIES

• Empirical Formula (Hill Notation): C6H11N3 · 2HCl
• Purity: (The product is pure based on elemental analysis results, NMR and MS spectra.)
• Apperance: white solid
• Solubility: H2O: >20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H318-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.

Description (简体中文)

Biochem/physiol Actions
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.