Gambogic acid

• Catalog No.: G8171
• CAS Number: 2752-65-0
• M. F.: C38H44O8
• M. W.: 628.75116
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0^2,^1^5.0^2,^1^9.0^4,^1^3.0^6,^1^1]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid
• IUPAC Traditional name: 4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0^2,^1^5.0^2,^1^9.0^4,^1^3.0^6,^1^1]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid
• Synonyms: Guttatic acid; Cambogic acid; B"-Guttiferrin; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid; Beta-Guttiferrin; Beta-Guttilactone; Guttic acid

DATABASE IDS

• CAS Number: 2752-65-0

PROPERTIES

• Empirical Formula (Hill Notation): C38H44O8
• Purity: ≥95% (HPLC)
• Apperance: yellow to orange powder
• Solubility: DMSO: ≥10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38
• RTECS: PB9268200
• Safety Statements: 26-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle.

Description (简体中文)

Biochem/physiol Actions
Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle.