GW3965 hydrochloride

• Catalog No.: G6295
• CAS Number: 405911-17-3
• M. F.: C33H32Cl2F3NO3
• M. W.: 618.5132896
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid hydrochloride
• IUPAC Traditional name: C33H31ClF3NO3 hydrochloride
• Synonyms: 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

DATABASE IDS

• PubChem SID: 24724494
• CAS Number: 405911-17-3
• MDL Number: MFCD08276920

PROPERTIES

• Empirical Formula (Hill Notation): C33H31F3ClNO3 · HCl
• Purity: ≥98% (HPLC)
• Apperance: white powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318-H413
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 22-41
• Safety Statements: 26-39
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.

Description (简体中文)

Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.