(Z)-Guggulsterone

• Catalog No.: G5168
• CAS Number: 39025-23-5
• M. F.: C21H28O2
• M. W.: 312.44582
• Purity: ≥89% (HPLC)

SYNONYMS

• IUPAC name: (1S,2R,10R,11S,15S)-14-ethylidene-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-ene-5,13-dione
• IUPAC Traditional name: (1S,2R,10R,11S,15S)-14-ethylidene-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-ene-5,13-dione
• Synonyms: (17Z)-Pregna-4,17(20)-diene-3,16-dione; 4,17(20)-trans-Pregnadiene-3,16-dione

DATABASE IDS

• MDL Number: MFCD01310757
• PubChem SID: 24278392
• CAS Number: 39025-23-5

PROPERTIES

• Empirical Formula (Hill Notation): C21H28O2
• Impurities: ≤5.4% E-form
• Purity: ≥89% (HPLC)
• Apperance: light yellow powder
• Solubility: DMSO: soluble5 mg/mL
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 37
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.

Description (简体中文)

Biochem/physiol Actions
(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.