Bactenecin

• Catalog No.: B2809
• M. F.: C63H118N24O13S2
• M. W.: 1483.89402
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-{[(4R,7S,10S,13S,16S,19S,22S,25S,28R)-28-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-4-methylpentanamido]-13,22-bis[(2S)-butan-2-yl]-10,25-bis(3-carbamimidamidopropyl)-6,9,12,15,18,21,24,27-octaoxo-7,16,19-tris(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosan-4-yl]formamido}-5-carbamimidamidopentanoic acid
• IUPAC Traditional name: (2S)-2-{[(4R,7S,10S,13S,16S,19S,22S,25S,28R)-28-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-4-methylpentanamido]-13,22-bis[(2S)-butan-2-yl]-10,25-bis(3-carbamimidamidopropyl)-7,16,19-triisopropyl-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosan-4-yl]formamido}-5-carbamimidamidopentanoic acid

DATABASE IDS

• MDL Number: MFCD00236810

PROPERTIES

• Empirical Formula (Hill Notation): C63H118N24O13S2
• Purity: ≥95% (HPLC)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11)
Other Notes
Peptide antibiotic, originally isolated from bovine neutrophil granules
Application
Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form 1. It is used to study the functional role of Trk1p in the mechanism of other antifungal peptides 2. It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components 3.

Description (简体中文)

Amino Acid Sequence
Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11)
Other Notes
Peptide antibiotic, originally isolated from bovine neutrophil granules
Application
Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form 1. It is used to study the functional role of Trk1p in the mechanism of other antifungal peptides 2. It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components 3.